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The groundbreaking original movie “Five” is an anthology of five short films exploring the impact of breast cancer on people’s lives.

The HBO special “Five” highlights the shared experience each short film’s title character endures from the moment of diagnosis, through an interconnected story arc that uses humor and drama to focus on the effect breast cancer and its different stages of diagnosis have on relationships and the way women perceive themselves while searching for strength, comfort, medical breakthroughs and, ultimately, a cure.

Directed by  Jennifer Aniston, Alicia Keys, Demi Moore, Independent Spirit Award winner Patty Jenkins (“Monster”) and Penelope Spheeris (“Wayne’s World”).

From executive producers Aniston, Marta Kauffman (“Friends”), Paula Wagner (“The Last Samurai,” “Mission: Impossible”), Kristin Hahn (“The Departed,” “The Switch”), Kevin Chinoy (“Greg the Bunny,” “Warren the Ape”) and Francesca Silvestri (“Greg the Bunny,” “Warren the Ape”).

The all-star ensemble cast includes Academy Award nominee Patricia Clarkson (“Pieces of April”), Rosario Dawson (“Sin City”), Lyndsy Fonseca (“How I Met Your Mother”), Ginnifer Goodwin (“Big Love”), Josh Holloway (“Lost”), Taylor Kinney (“The Vampire Diaries”), Jenifer Lewis (“The Princess and the Frog”), Jennifer Morrison (“House M.D.”), Kathy Najimy (“WALL-E”), Golden Globe Award winner Bob Newhart (“Horrible Bosses”), Annie Potts (“Law & Order: SVU”), Tracee Ellis Ross (“Girlfriends”), Emmy and Golden Globe winner Tony Shalhoub (“Monk”), and Emmy nominees Jeffrey Tambor (“Arrested Development”) and Jeanne Tripplehorn (“Big Love”).

Five premiers Monday night October 10 on HBO at 9 PM.

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